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The proinflammatory phenotype could be the dominant phenotype of immune cells in T2DM. In T2DM, M1 macrophages are the dominant immune cells that cause inflammation in islets.352,353,354 The expression levels of PPARγ in macrophages from T2DM patients are decreased, and macrophage-precise PPARγ controls M2 macrophage activation.355,356 The propor